古往今來，人類使用了許多不同的止痛方法。然而仍然有一些疼痛癥狀無法得到有效緩解，由于不同程度的鎮(zhèn)痛藥物不良反應(yīng)，或藥效強(qiáng)度和持續(xù)時(shí)間都不理想，對(duì)疼痛的預(yù)防和治療仍達(dá)不到理想的程度。

Throughout the ages, man has used many different remedies for pain relief.However, there are still some pain symptoms that can't be effectively alleviated, because of different degrees of analgesic drug adverse reactions or efficacy intensity and duration is not ideal. Thus, the prevention and treatment of pain is still not up to the ideal degree.

具有不同作用機(jī)制和不同鎮(zhèn)痛類型的各種止痛藥需要在臨床試驗(yàn)前通過相應(yīng)的動(dòng)物模型進(jìn)行評(píng)估。當(dāng)動(dòng)物在實(shí)驗(yàn)方案中經(jīng)理疼痛時(shí)，會(huì)觸發(fā)一系列生理、激素、生化和行為變化，這與人類的反應(yīng)方式如出一撤。

Various analgesics with different mechanisms of action and different types of analgesia need to be evaluated by corresponding animal models before clinical trials.When animals experience pain during an experimental protocol, a cascade of physiological, hormonal ,biochemical, and behavioral alterations is triggered that's simile the same way of human reaction.

我們可以選擇相應(yīng)的鎮(zhèn)痛動(dòng)物模型來評(píng)價(jià)新的鎮(zhèn)痛藥物。疼痛的動(dòng)物模型旨在模擬不同的臨床疾病，以更好地評(píng)估潛在的機(jī)制和潛在的治療方法。

Therefore, we can choose the corresponding pain animal model to evaluate the new analgesic drugs.Animal models of pain are designed to mimic distinct clinical diseases to better evaluate underlying mechanisms and potential treatments.

目前，美迪西具有不同類型的疼痛包括急性疼痛、炎癥性疼痛和神經(jīng)性疼痛。我們已經(jīng)開發(fā)了許多常見的方法，用于誘導(dǎo)與臨床疼痛綜合征相關(guān)的每種疼痛表型，以及評(píng)估每種模型腫疼痛的主要行為測試。

Currently, Medicilon possesses different types of pain, including acute pain, inflammatory pain, and neuropathic pain.We have developed many common methods used for inducing each of the pain phenotypes related to clinical pain syndromes,as well as the main behavioral tests for assessing pain in each model.

我們也開發(fā)了各種臨床相關(guān)的疼痛模型，這些模型已經(jīng)過驗(yàn)證，以有效地測試新的治療候選藥物。

We have developed a variety of clinically relevant pain models that have been validated to effectively test new therapeutic candidates.