根據(jù)GLP-1R作用時(shí)間，GLP-1R激動(dòng)劑可以分為短效和長(zhǎng)效兩大類。

Based on their ability to activate GLP-1 receptor，GLP-1 receptor agonists can be classified as short- acting and long-acting GLP-1R agonist.

短效GLP-1R 激動(dòng)劑，需要每日一次或者每日兩次給藥。

Short-acting GLP-1R agonists are required to give either a once daily (QD) or twice-daily（BID）dosing.

如艾塞那肽和利西拉肽等，長(zhǎng)效GLP-1R激動(dòng)劑是對(duì)化合物分子進(jìn)行了一些結(jié)構(gòu)修飾，這樣可以增強(qiáng)其作用時(shí)間，同時(shí)保留其作用于GLP-1R 的能力.如杜拉魯肽、阿必魯肽等，每周給藥一次即可。

For example Exenatide and Lixisenatide, long acting GLP-1R agonists have undergone some structural modifications to enhance their duration of action while retaining their ability to act on the GLP-1 receptors. For example Albiglutide,Dulaglutide, once weekly.

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